Hats off to Misha Angrist over at Genome Boy for bringing this fascinating story about personal genomic experiments that ran in Nature Medicine to my attention. Raymond McCauley and a small team of DIY-researchers wanted to know how effective different types of vitamins were for clearing "undesirable" amino acids from their bodies. One of the supplements they investigated was a standard, over-the-counter vitamin B tablet. But the other, was a more highly active B vitamin, called L-methylfolate. McCauley's genetic profile differed from the rest of his team in two particular SNPs (he was homozygous at both locations).
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